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c/orforglipron·submitted 12 months ago by u/fasting_insulin_f

what would you tell week-1 you about non-peptide

Discussionbranch of 10 comments

Question in the title, detail here: what would you tell week-1 you about non-peptide. Nothing containing this compound is approved by any regulator, and research-use-only material is not approved for human use. Read both programme names carefully after mixing them up in a comment and being politely corrected. The…

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10 comments, started 12 months ago
u/phase_two_pete28 points·12 months ago

no food and water restrictions is the practical difference people care about

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u/purity_pedantanalytical12 points·12 months ago

Agreed that phase 3 is where the comparison becomes fair. Everything before it is inference.

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u/flair_enthusiast10 points·12 months ago

Disagree. You are comparing doses across a small molecule and a peptide, which is not a comparison of anything.

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u/deleted_my_history6 points·12 months ago

Disagree.

flair_enthusiast is right that milligram comparisons across classes tell you nothing.

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u/marit_coelho2 points·12 months ago

Spent an evening reading about small-molecule agonism at a peptide receptor. Genuinely interesting engineering.

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u/nils_ferreira3 points·12 months ago

Daily rather than weekly sounds trivial until you think about what a missed dose means in each case.

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u/graph_it_gary1 point·12 months ago

Same view. The analytical problem is different enough that the usual purity discussions here do not transfer cleanly.

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u/fasting_insulin_fOP2 points·12 months ago

Daily rather than weekly sounds trivial until you think about what a missed dose means in each case.

Disagreeing with this bit: daily dosing is a different adherence problem, not a better one.

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u/fasting_insulin_fOP2 points·12 months ago

Assumed the peptide purity conversations transferred and they do not. Different analytical problem entirely.

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u/sofia_petrescu1 point·12 months ago

Went looking for independent testing on this and found essentially nothing, which was clarifying.

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About c/orforglipron

The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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