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c/orforglipron·submitted 12 months ago by u/fasting_insulin_f

what would you tell week-1 you about non-peptide

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Question in the title, detail here: what would you tell week-1 you about non-peptide. Nothing containing this compound is approved by any regulator, and research-use-only material is not approved for human use. Read both programme names carefully after mixing them up in a comment and being politely corrected. The…

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9 comments, started 12 months ago
u/zeynep_ndiaye54 points·12 months ago

Oral semaglutide is a peptide co-formulated with an absorption enhancer and carries food and water timing requirements. A small molecule does not have that constraint, which is the practical distinction.

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u/muscle_cramp_mo34 points·12 months ago

Phase 2 or phase 3?

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u/chidi_yilmaz-28 points·12 months ago

Daily dosing, so what does the exposure profile look like across the day?

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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