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c/orforglipron·submitted 2 months ago by u/lucia_bruun

three years of small molecule threads, summarised so you do not have to read them

Paperbranch of 10 comments

three years of small molecule threads, summarised so you do not have to read them. Change my mind, genuinely — I have no stake in being right about this. Analytically this is a small-molecule identity and purity problem, not a peptide one. The methods, the impurity classes and the reference standards are all…

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10 comments, started 2 months ago
u/marit_sandvik121 points·2 months ago·edited

Because it is not a peptide, it is not subject to the same degradation pathways, does not require the absorption enhancers used for oral peptides, and can be formulated as a conventional tablet.

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u/ahmed_okafor34 points·2 months ago

Phase 2 or phase 3?

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u/lucia_bruunOP21 points·2 months ago

the boards keep comparing it to injectables at matched doses, which is meaningless

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u/trialwatch_theoMOD63 points·2 months ago

Corrected a cross-class dose comparison in the title. The body is untouched.

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u/salma_almeida28 points·2 months ago

oral semaglutide is a peptide with an absorption enhancer, this is not that

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u/brigade_detector7 points·2 months ago

Compared milligram figures across two completely different molecule classes in a comment. Deserved the correction.

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u/fabio_lehtinen3 points·2 months ago

small molecule, not a peptide, and that changes everything about it

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u/bruno_dumitru26 points·2 months ago

Correction: that is the oral peptide product, which is a different thing entirely. This one is a small molecule.

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u/hsa_math92 points·2 months ago·edited

Read both programme names carefully after mixing them up in a comment and being politely corrected.

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u/lucia_bruunOP-20 points·2 months ago

Has anyone here seen independent identity testing on this?

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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