[Question] lowest effective dose — what am I missing here
The title is the whole question — lowest effective dose — what am I missing here — but here is why I am asking. Withdrawal studies in this class consistently show substantial regain after discontinuation. That is a pharmacological finding about a chronic condition, not a statement about anyone’s discipline. The two…
Retitled — this is maintenance, not a plateau, and the original framing was doing damage.
a few kilos of drift is not a relapse
Two years at maintenance. The logistics are the only remaining work — ordering, storing, remembering.
I would not treat a two-kilo range as drift requiring action. That is ordinary weight variation.
Interval stretching changes the exposure profile: with a week-long half-life, moving to ten or twelve days lowers trough concentration more than it lowers average exposure. That is why appetite return is often the first thing noticed.