how much of what we believe about dose stretching actually comes from regain threads

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about dose stretching actually comes from regain threads.

On stopping, since it is the question underneath most posts here.

Withdrawal studies in this class show substantial regain after discontinuation, consistently, across compounds. Appetite returns first, typically well before the scale moves. That is a statement about the pharmacology of a chronic condition, not about anybody’s character, and the framing matters because people quit in shame over an entirely predictable result.

If you are going to stop — for cost, for supply, for any reason — the useful preparation is deciding in advance what you will watch for and what your plan is when appetite comes back. Doing that in advance is much easier than doing it in a panic, and it is a conversation to have with someone who knows your history.

Interval stretching changes the exposure profile: with a week-long half-life, moving to ten or twelve days lowers trough concentration more than it lowers average exposure. That is why appetite return is often the first thing noticed.

Withdrawal studies in this class consistently show substantial regain after discontinuation. That is a pharmacological finding about a chronic condition, not a statement about anyone’s discipline.

If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.