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switched from 1.7mg to 2.4mg and nausea got better, not worse

Long Term Well Actually ×2 Slow Clap ×1

switched from 1.7mg to 2.4mg and nausea got better, not worse. It is the sort of thing everyone half-believes and nobody writes down.

The numbers the title promised, since a headline without them is worthless: 1.7mg and 2.4mg. Everything below is context for those.

Stretched from seven to ten days and then to twelve over about four months. Appetite told me where the limit was before the scale did.

Chased the last three kilos with a dose increase and got a fortnight of early fullness and no change in the number.

If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.

2,124 up / 283 down88% upvoted53 commentsid o7wqie6 Apr 2025

53 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/yara_antonsen273 points·1 year ago

Withdrawal studies in this class consistently show substantial regain after discontinuation. That is a pharmacological finding about a chronic condition, not a statement about anyone’s discipline.

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u/omar_eriksen60 points·1 year ago

None of this is a taper plan. What dose holds for you is a question for somebody with your history in front of them.

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u/adnan_sandvik220 points·1 year ago·edited

Body weight varies by a couple of kilos over days in stable people through fluid, glycogen and gut content. A range is not a trend.

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u/osman_ferrari176 points·1 year ago·edited

Interval stretching changes the exposure profile: with a week-long half-life, moving to ten or twelve days lowers trough concentration more than it lowers average exposure. That is why appetite return is often the first thing noticed.

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u/nadia_trevinoOP253 points·1 year ago

Weigh monthly now. Best change I made in the whole run and it cost nothing.

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u/nadia_trevinoOP134 points·1 year ago

The habits from the losing phase are what carry it now. That is not inspirational, it is just what happened.

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u/noor_vermeulen57 points·1 year ago

Right — appetite returns before the scale moves, which is the early signal people miss.

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u/oskar_malinowski37 points·1 year ago

maintenance is a phase, not a finish line

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u/zaid_eriksen15 points·1 year ago

Drifted up 13kg over a winter and panicked. It came back off without any change, which is apparently just what weight does.

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u/nadia_trevinoOP33 points·1 year ago

That is a range, not a trend. Two weigh-ins 15 days apart cannot distinguish them.

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u/priya_weiss-25 points·1 year ago

What dose are you holding, and for how long now?

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u/adnan_sandvik1 point·1 year ago

This. The withdrawal data is not ambiguous and framing regain as a personal failure is both wrong and cruel.

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u/priya_weiss1 point·1 year ago

regain after stopping is the expected outcome, not a personal failure

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[removed]1 point·1 year ago

[removed by moderator]

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u/rasmus_petrescu1 point·1 year ago

Not convinced. Interval stretching changes your exposure profile, not just the total, and the two are not equivalent.

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u/hassan_ostergaard1 point·1 year ago

Push back: that is not a plateau, that is maintenance. You have arrived and you are describing it as a failure.

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u/aleksi_eriksen1 point·1 year ago

find the dose that holds, then stop optimising

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u/paper_trail_paulavetting0 points·1 year ago

Not convinced.

This reframing is the most useful thing on the board for anyone approaching this phase.

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u/cold_chromatogram_only1 point·1 year ago

Two years at maintenance. The logistics are the only remaining work — ordering, storing, remembering.

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u/hugo_norgaard1 point·1 year ago

Correction: that trial measured regain after withdrawal, not failure of the drug during treatment. Very different claim.

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u/adnan_sandvik1 point·1 year ago·edited

Cosigning on planning it in advance. Deciding what maintenance looks like while still losing is much easier than deciding it in a panic.

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u/lina_novak1 point·1 year ago

Has appetite changed, or only the scale?

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u/kasper_cabrera1 point·1 year ago

What does your weigh-in frequency look like at this point?

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u/yara_antonsen1 point·1 year ago

Stretching the interval, reducing the dose, or both?

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u/tomas_lokken1 point·1 year ago

the habits are the part that has to outlive the dose

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u/dario_petrescu1 point·1 year ago

Maintenance is the phase with the least published guidance and the most individual variation, which is precisely why board consensus here is worth less than usual.

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u/maintenance_mode_maxmaintenance1 point·1 year ago

Agreed. Lowest effective dose is the actual maintenance question and it gets almost no airtime next to the escalation threads.

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u/nadia_trevino93 points·1 year ago

stretching the interval is not the same as reducing the dose

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u/kasper_cabrera27 points·1 year ago

appetite returns before the scale acknowledges anything

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The part nobody posts about: what happens at goal weight. Finding a lowest effective dose, dose-interval stretching, regain risk data, muscle retention, the psychology of not having a number to chase, and staying on indefinitely versus tapering.

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