[Discussion] the lowest effective dose advice in here is 2 years out of date
the lowest effective dose advice in here is 2 years out of date. I have gone back and forth on this for months.
Hard numbers: 2 years. Anything softer than that is flagged as an impression.
Withdrawal studies in this class consistently show substantial regain after discontinuation. That is a pharmacological finding about a chronic condition, not a statement about anyone’s discipline.
Interval stretching changes the exposure profile: with a week-long half-life, moving to ten or twelve days lowers trough concentration more than it lowers average exposure. That is why appetite return is often the first thing noticed.
Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.
best — the order this archive was captured in
Dose reduction and interval extension are different interventions. Halving the dose keeps the rhythm and lowers the level; stretching keeps the level and lowers the frequency, with a lower trough.
maintenance is where the logistics finally get boring, which is the point
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Weigh monthly now. Best change I made in the whole run and it cost nothing.
What does your weigh-in frequency look like at this point?
Correcting myself: 12 months at maintenance, not the figure I posted. I keep rounding it up.