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switched from 7.5mg to 10mg and injection-site soreness got better, not worse

Discussionbranch of 9 comments

switched from 7.5mg to 10mg and injection-site soreness got better, not worse. Making the case below, and I expect to lose some of it in the comments. Pulling the figures out of the title: 7.5mg and 10mg. All of it is written down as it happened rather than reconstructed. Been at maintenance for 16 months on 1.0mg.…

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9 comments, started 2 years ago
u/osman_ferrari64 points·2 years ago

Body weight varies by a couple of kilos over days in stable people through fluid, glycogen and gut content. A range is not a trend.

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u/kaplan_meier_kim22 points·2 years ago

find the dose that holds, then stop optimising

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u/ferritin_low-26 points·2 years ago

Withdrawal studies in this class consistently show substantial regain after discontinuation. That is a pharmacological finding about a chronic condition, not a statement about anyone’s discipline.

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u/nikhil_lindqvist1 point·2 years ago

appetite returns before the scale acknowledges anything

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u/cold_chromatogram_onlyOP1 point·2 years ago

What is the plan if the drift continues for another month?

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u/nnt_nate1 point·2 years ago

What is the plan if the drift continues for another month?

Disagreeing with this bit: a two-kilo range is not drift and treating it as a problem creates one.

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u/cold_chromatogram_onlyOP1 point·2 years ago

Small fix — you have described interval stretching and called it a dose reduction. The exposure profiles differ.

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u/usp_appendixcompendial1 point·2 years ago

the trials that looked at withdrawal are unambiguous about what follows

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u/nabila_espinoza1 point·2 years ago

Withdrawal studies in this class consistently show substantial regain after discontinuation.

Adding one thing — decide what maintenance looks like before you arrive at it.

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