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c/hplc·submitted 5 days ago by u/careful_gradient

[Method] the gradient everyone uses for sema and why it under-resolves the des-amido

Methodbranch of 8 comments

Right, the HPLC question again, but with numbers this time. I have 21 data points over 38 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am describing…

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8 comments, started 4 days ago
u/georgi_tamm59 points·4 days ago

the detector wavelength matters more than people think

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u/ewan_tulloch17 points·4 days ago

the detector wavelength matters more than people think

Adding to this: integration is doing more work than the comment implies.

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u/yara_bakken19 points·4 days ago

related substances are where the story lives, not the main peak

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u/camila_lindqvist4 points·4 days ago

Small correction: the trial was 2 weeks, not 39. Does not change your point but people will quote it.

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u/hamza_weiss2 points·4 days ago

Small correction: the trial was 24 weeks, not 7. Does not change your point but people will quote it.

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u/anya_erdogan48 points·4 days ago

That is net peptide content, not purity. Different number, different meaning.

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u/medutest_mel17 points·4 days ago·edited

This is the correct method framing. Column and gradient are load-bearing fields.

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u/yara_bakken6 points·4 days ago

This is the correct method framing. Column and gradient are load-bearing fields.

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