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c/glp1women·submitted 9 months ago by u/sterile_field_steph

[Results] 25 weeks, 12kg, and contraception was the hard part

Resultsbranch of 9 comments

25 weeks, 12kg, and contraception was the hard part, logged the same way every week so the comparison is at least internally fair. 25 weeks and 12kg — those are the numbers, and they are the ones I am willing to defend. Insulin resistance is a common feature in PCOS, which is why the metabolic conversation overlaps…

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9 comments, started 9 months ago
u/nnt_nate106 points·9 months ago

Started logging the cycle in the same sheet as the dose. Three months later the pattern was obvious and it had been invisible before.

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u/ewan_tulloch89 points·9 months ago

Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.

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u/sterile_field_stephOP46 points·9 months ago

Correction: that trial did not enrol the population being discussed, so it cannot support the claim.

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u/neha_falk51 points·9 months ago

Brought the cycle-annotated log to an appointment and it changed the conversation completely.

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u/nnt_nate31 points·9 months ago

the same dose can feel different at different points in the month

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u/sterile_field_stephOP0 points·9 months ago

Is this a PCOS diagnosis or an insulin resistance finding?

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u/kenji_demir55 points·9 months ago

Have you asked a pharmacist about the absorption question specifically?

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u/rasmus_petrescu25 points·9 months ago

Telogen shedding follows a period of significant weight change rather than a specific compound, and it resolves.

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u/idris_kimani0 points·9 months ago

Started logging the cycle in the same sheet as the dose.

Agreed, and the research gap being real rather than imagined is worth saying out loud.

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The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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