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c/glp1women·posted 1 year ago by u/sterile_field_steph

insulin resistance — my 21-week log, condensed into one table

Discussion Clean Column ×1 Sourced ×3

insulin resistance — my 21-week log, condensed into one table. Making the case below, and I expect to lose some of it in the comments.

Brought the cycle-annotated log to an appointment and it changed the conversation completely.

Went looking for trial data on the specific question asked here and found the population had not been enrolled.

The hair shedding was the thing that frightened me most and the thing that mattered least. It stopped.

Ask me anything specific. Anything general I will probably get wrong.

2,562 up / 134 down95% upvoted68 commentsid 62esjb19 Aug 2024

68 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/santiago_marchetti178 points·1 year ago

Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.

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u/sterile_field_stephOP-19 points·1 year ago

Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.

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u/ferran_mensah145 points·1 year ago

cycle timing changes how the same week feels

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u/devils_advocate_d80 points·1 year ago

Agreed that the vocabulary here is imprecise and it causes people to answer different questions to the ones asked.

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u/sulphur_burps_sue131 points·1 year ago

Perimenopausal, or is that a separate question?

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u/low_appetite_lisaMOD73 points·1 year ago·edited

Pointing the contraception question at a pharmacist. They can answer it properly and we cannot.

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u/rina_sobczak89 points·1 year ago

the research gap is real and it is not your imagination

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u/zaid_grimaldi67 points·1 year ago·edited

That trial did not enrol the population you are asking about, so it cannot answer this.

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u/dilara_szabo20 points·1 year ago

the same dose can feel different at different points in the month

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u/ferran_laurent23 points·1 year ago

ask a clinician about anything involving pregnancy, without exception

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u/zaid_roos0 points·1 year ago

That trial did not enrol the population you are asking about, so it cannot answer this.

Agreed, and the research gap being real rather than imagined is worth saying out loud.

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u/tared_twice42 points·1 year ago

Are you asking about the compound, the weight loss, or both?

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u/tl_dr_tina13 points·1 year ago

This. Anything involving pregnancy or contraception goes to a clinician, and this board should keep saying so.

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u/zeynep_weiss6 points·1 year ago

The same dose genuinely feels different at different points in the month for me. Took a year to notice and it was in the log the whole time.

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u/ines_boateng6 points·1 year ago

nothing on this board is a substitute for someone who knows your history

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u/ferran_laurent4 points·1 year ago

PCOS and insulin resistance are the thread that runs through this board

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u/foam_head_fred35 points·1 year ago

The one practical change that makes this board’s hardest questions tractable: annotate your log with the cycle.

Hormonal variation affects appetite, fluid and symptom intensity in its own right. Without the annotation, a log shows a dose, a week and a set of symptoms that appear to move at random. With it, patterns that were invisible become obvious in about three months.

Members here who have done it consistently report the same thing: the same dose feels genuinely different at different points, and knowing that in advance converts a confusing fortnight into an expected one. It also makes a much better document to bring to an appointment.

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u/elin_lindqvist24 points·1 year ago

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

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u/ismael_chukwu31 points·1 year ago

PCOS is a diagnosis, not a description, and it matters which you mean

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u/bastian_moreau35 points·1 year ago

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

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u/georgi_haddad25 points·1 year ago

Push back: PCOS as a diagnosis and insulin resistance as a finding are not interchangeable, and the thread is using them as one.

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u/lipid_panel_larrybloodwork11 points·1 year ago

the trials were not designed to answer most of the questions asked here

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u/bastian_aalto15 points·1 year ago

fertility can change with weight loss and that surprises people

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[removed]11 points·1 year ago

[removed by moderator]

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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