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c/glp1women·posted 1 year ago by u/ewan_tulloch

[Discussion] we are measuring contraception at the wrong time and calling it noise

Discussion Well Actually ×7 Sourced ×3

we are measuring contraception at the wrong time and calling it noise. Not a hot take, just something I have not seen said plainly here.

Went looking for trial data on the specific question asked here and found the population had not been enrolled.

Asked a pharmacist about the absorption question rather than the internet. Ten minutes, clear answer, done.

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

I will update this if the picture changes rather than quietly leaving it up.

3,202 up / 991 down76% upvoted56 commentsid 5sf6uc11 Sep 2024

56 comments

25 in this archive, depth 5

best — the order this archive was captured in

u/gentle_correctionMOD458 points·1 year ago

Standing reminder: nothing here is medical advice, and pregnancy questions go to a clinician without exception.

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u/ewan_tullochOP235 points·1 year ago

Has this been raised with whoever prescribes?

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u/dose_creep_dan-2 points·1 year ago

Where in the cycle does this fall, if you are tracking it?

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u/tl_dr_tina327 points·1 year ago

Telogen shedding follows a period of significant weight change rather than a specific compound, and it resolves.

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[deleted]127 points·1 year ago

[deleted]

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u/rasmus_petrescu99 points·1 year ago

the trials were not designed to answer most of the questions asked here

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u/lipid_panel_larrybloodwork169 points·1 year ago·edited

Disagree — that is a general claim about absorption and the specific question needs a pharmacist rather than a board.

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u/dose_creep_dan59 points·1 year ago

ask a clinician about anything involving pregnancy, without exception

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u/ewan_tullochOP46 points·1 year ago

the research gap is real and it is not your imagination

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u/jarno_karlsen21 points·1 year ago

PCOS is a diagnosis, not a description, and it matters which you mean

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u/vitamin_d_void33 points·1 year ago

Perimenopausal, or is that a separate question?

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u/valeria_cardoso95 points·1 year ago

I would not read one person’s cycle-linked experience as a general pattern. The variation here is enormous.

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u/ewan_tullochOP39 points·1 year ago

Is this a PCOS diagnosis or an insulin resistance finding?

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u/careful_gradient112 points·1 year ago

The one practical change that makes this board’s hardest questions tractable: annotate your log with the cycle.

Hormonal variation affects appetite, fluid and symptom intensity in its own right. Without the annotation, a log shows a dose, a week and a set of symptoms that appear to move at random. With it, patterns that were invisible become obvious in about three months.

Members here who have done it consistently report the same thing: the same dose feels genuinely different at different points, and knowing that in advance converts a confusing fortnight into an expected one. It also makes a much better document to bring to an appointment.

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u/elodie_kuipers62 points·1 year ago

Have you asked a pharmacist about the absorption question specifically?

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u/micro_bump_mick48 points·1 year ago

Careful — anything touching pregnancy is not a board question in any form.

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u/kaia_fonseca94 points·1 year ago

cycle timing changes how the same week feels

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u/ines_boateng23 points·1 year ago

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

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u/lukas_vermeulen16 points·1 year ago

That is a general statement about gastric emptying, and the question was about a specific product.

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u/neha_falk14 points·1 year ago

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an

This is the practical fix for half the confusing weeks on this board — annotate the cycle.

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u/nils_tulloch7 points·1 year ago

This is the practical fix for half the confusing weeks on this board — annotate the cycle.

Disagreeing with this line: the absorption question has a product-specific answer and a pharmacist has it.

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u/rasmus_petrescu4 points·1 year ago

Disagreeing with this line: the absorption question has a product-specific answer and a pharmacist has it.

nils_tulloch is right that a diagnosis and a finding are different things here.

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u/ines_boateng9 points·1 year ago

Same. Perimenopause overlapping with all of this is the least documented area on the whole site.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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