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c/glp1women·posted 1 year ago by u/dilara_szabo

PCOS — my 15-week log, condensed into one table

Caution Well Actually ×7 Clean Column ×2 Receipts ×2

PCOS — my 15-week log, condensed into one table. It is the sort of thing everyone half-believes and nobody writes down.

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

Questions about oral contraceptive absorption and gastric emptying are legitimate pharmacology questions with product-specific answers. A pharmacist can answer them properly; a board cannot.

Fertility can change with weight loss and improved insulin sensitivity. That is a well-described phenomenon and worth knowing about in advance rather than discovering.

Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.

2,833 up / 206 down93% upvoted55 commentsid 44hkoi17 Jan 2025

55 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/tired_ledger_ftw459 points·1 year ago

Anything involving pregnancy, contraception efficacy or fertility planning belongs with a clinician. That is not a disclaimer, it is where the answers actually are.

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u/valeria_cardoso-28 points·1 year ago

PCOS and insulin resistance are the thread that runs through this board

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u/karim_restrepo1 point·1 year ago

say what you are actually asking, the vocabulary here is imprecise

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u/bastian_eriksen1 point·1 year ago

I would not read one person’s cycle-linked experience as a general pattern. The variation here is enormous.

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u/dilara_szabo1 point·1 year ago

Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.

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u/dilara_szaboOP1 point·1 year ago

Are you logging the cycle alongside the dose?

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u/hair_shed_hannahMOD303 points·1 year ago

Retitled to distinguish a cycle-linked pattern from a dose-linked one.

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u/mei_cardoso211 points·1 year ago

Has this been raised with whoever prescribes?

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u/bastian_aalto294 points·1 year ago

Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.

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u/idris_kimani197 points·1 year ago

Correction: that trial did not enrol the population being discussed, so it cannot support the claim.

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u/blunt_coldbox_202453 points·1 year ago

Telogen shedding follows a period of significant weight change rather than a specific compound, and it resolves.

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u/dilara_szaboOP180 points·1 year ago

Where in the cycle does this fall, if you are tracking it?

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u/tired_ledger_ftw75 points·1 year ago·edited

Right, and symptom patterns tracking the cycle rather than the dose explains a lot of confusing weeks.

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u/sulphur_burps_sue56 points·1 year ago

Is this a PCOS diagnosis or an insulin resistance finding?

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[removed]54 points·1 year ago

[removed by moderator]

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u/dilara_szaboOP141 points·1 year ago

Started logging the cycle in the same sheet as the dose. Three months later the pattern was obvious and it had been invisible before.

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u/usp_appendixcompendial114 points·1 year ago

contraception absorption questions are real and they are worth asking about properly

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u/cesar_oyelaran32 points·1 year ago

ask a clinician about anything involving pregnancy, without exception

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u/devils_advocate_d61 points·1 year ago

cycle timing changes how the same week feels

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u/greta_nilsen188 points·1 year ago

Insulin resistance is a common feature in PCOS, which is why the metabolic conversation overlaps so heavily with this board. A diagnosis and a finding are still different things and the distinction matters for what the evidence says.

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u/rui_only_ro147 points·1 year ago

Small fix — insulin resistance is a feature commonly seen in PCOS, not a synonym for it.

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u/ewan_tulloch39 points·1 year ago

symptom patterns can track the cycle rather than the dose

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u/usp_appendixcompendial110 points·1 year ago

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

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u/tared_twice74 points·1 year ago

Why the evidence base here is thin, which is not your imagination.

The major trial programmes were designed around endpoints that do not answer most of the questions this board asks: cycle interactions, contraception, fertility, perimenopause. The populations were not enrolled to answer them and the endpoints were not chosen to measure them.

So when you search and find nothing, that is usually the actual state of the literature rather than a failure of searching. What follows practically: be precise about your question, take the pharmacology parts to a pharmacist who can look up product-specific information, and treat confident answers on this board — including the ones that agree with you — with more caution than usual.

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u/nayeli_iyer55 points·1 year ago

Push back: PCOS as a diagnosis and insulin resistance as a finding are not interchangeable, and the thread is using them as one.

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u/idris_kimani15 points·1 year ago

Cosigning on fertility changing with weight loss. It catches people who were not expecting it at all.

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u/zaid_roos3 points·1 year ago

the same dose can feel different at different points in the month

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u/idris_kimani4 points·1 year ago

iron and ferritin questions come up here more than anywhere else on the site

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u/ewan_tulloch1 point·1 year ago

This. Anything involving pregnancy or contraception goes to a clinician, and this board should keep saying so.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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