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c/glp1women·posted 4 months ago by u/gustav_lindholm

[Discussion] can we stop arguing about fertility until somebody posts a number

Discussion Receipts ×4

Genuine question, and the title is the question: can we stop arguing about fertility until somebody posts a number.

Questions about oral contraceptive absorption and gastric emptying are legitimate pharmacology questions with product-specific answers. A pharmacist can answer them properly; a board cannot.

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

Insulin resistance is a common feature in PCOS, which is why the metabolic conversation overlaps so heavily with this board. A diagnosis and a finding are still different things and the distinction matters for what the evidence says.

Ask me anything specific. Anything general I will probably get wrong.

491 up / 94 down84% upvoted13 commentsid 30g0en21 Mar 2026

13 comments

6 in this archive, depth 4

best — the order this archive was captured in

u/devils_advocate_d74 points·4 months ago·edited

Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.

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u/milan_wikstrom45 points·4 months ago

Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.

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u/joaquin_wojcik44 points·4 months ago

This. Anything involving pregnancy or contraception goes to a clinician, and this board should keep saying so.

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u/gustav_lindholmOP19 points·4 months ago

This.

This is the practical fix for half the confusing weeks on this board — annotate the cycle.

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u/dilara_szabo16 points·4 months ago

That trial did not enrol the population you are asking about, so it cannot answer this.

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u/bastian_aalto24 points·4 months ago

Small fix — insulin resistance is a feature commonly seen in PCOS, not a synonym for it.

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The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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