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c/glp1women·posted 1 year ago by u/honest_syringe_2025

my fasting insulin moved and I cannot work out whether contraception is why

Question Cold Box ×5

Posting this as a discussion rather than a claim: my fasting insulin moved and I cannot work out whether contraception is why.

Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.

Fertility can change with weight loss and improved insulin sensitivity. That is a well-described phenomenon and worth knowing about in advance rather than discovering.

Questions about oral contraceptive absorption and gastric emptying are legitimate pharmacology questions with product-specific answers. A pharmacist can answer them properly; a board cannot.

If somebody has the same thing measured a different way, post it next to mine and we will see whether they agree.

1,121 up / 318 down78% upvoted37 commentsid 2qjk7n15 Nov 2024

37 comments

19 in this archive, depth 5

best — the order this archive was captured in

u/reads_the_wiki115 points·1 year ago

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

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u/tared_twice26 points·1 year ago

Have you asked a pharmacist about the absorption question specifically?

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[removed]85 points·1 year ago

[removed by moderator]

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u/gentle_correctionMOD89 points·1 year ago

Standing reminder: nothing here is medical advice, and pregnancy questions go to a clinician without exception.

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u/ewan_zielinski61 points·1 year ago

Standing reminder: nothing here is medical advice, and pregnancy questions go to a clinician without exception.

Disagreeing with this line: the absorption question has a product-specific answer and a pharmacist has it.

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u/nnt_nate105 points·1 year ago·edited

I would not read one person’s cycle-linked experience as a general pattern. The variation here is enormous.

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u/rasmus_petrescu31 points·1 year ago

Agreed that the vocabulary here is imprecise and it causes people to answer different questions to the ones asked.

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u/mateusz_mensah63 points·1 year ago·edited

iron and ferritin questions come up here more than anywhere else on the site

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u/joaquin_trevino48 points·1 year ago

Cosigning on fertility changing with weight loss. It catches people who were not expecting it at all.

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u/lipid_panel_larrybloodwork40 points·1 year ago·edited

That trial did not enrol the population you are asking about, so it cannot answer this.

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u/viktor_laurent25 points·1 year ago

Anything involving pregnancy, contraception efficacy or fertility planning belongs with a clinician. That is not a disclaimer, it is where the answers actually are.

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u/micro_bump_mick6 points·1 year ago·edited

Disagree — that is a general claim about absorption and the specific question needs a pharmacist rather than a board.

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u/ferran_laurent4 points·1 year ago

Careful — anything touching pregnancy is not a board question in any form.

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u/nils_tulloch0 points·1 year ago

Careful — anything touching pregnancy is not a board question in any form.

This is the practical fix for half the confusing weeks on this board — annotate the cycle.

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u/hair_shed_hannah21 points·1 year ago

Small fix — insulin resistance is a feature commonly seen in PCOS, not a synonym for it.

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u/karl_fischer_kev6 points·1 year ago

fertility can change with weight loss and that surprises people

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u/honest_syringe_2025OP4 points·1 year ago

Correction: that trial did not enrol the population being discussed, so it cannot support the claim.

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u/coa_forgery_watch3 points·1 year ago

Correction: that trial did not enrol the population being discussed, so it cannot support the claim.

Adding the one thing nobody warns about — fertility can change, and quickly.

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u/idris_kimani18 points·1 year ago·edited

Telogen shedding follows a period of significant weight change rather than a specific compound, and it resolves.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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