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c/glp1women·posted 4 months ago by u/bastian_eriksen

15 months in and insulin resistance is still the thing I get wrong

PCOS Slow Clap ×1

Reporting in. 15 months in and insulin resistance is still the thing I get wrong.

15 months. Those are measured, not estimated, and not rounded up in my favour.

Brought the cycle-annotated log to an appointment and it changed the conversation completely.

The one practical change that makes this board’s hardest questions tractable: annotate your log with the cycle.

Hormonal variation affects appetite, fluid and symptom intensity in its own right. Without the annotation, a log shows a dose, a week and a set of symptoms that appear to move at random. With it, patterns that were invisible become obvious in about three months.

Members here who have done it consistently report the same thing: the same dose feels genuinely different at different points, and knowing that in advance converts a confusing fortnight into an expected one. It also makes a much better document to bring to an appointment.

Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.

533 up / 99 down84% upvoted20 commentsid 2qgepo11 Mar 2026

20 comments

14 in this archive, depth 3

best — the order this archive was captured in

u/dose_creep_dan111 points·4 months ago

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

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u/hair_shed_hannahMOD60 points·4 months ago

Retitled to distinguish a cycle-linked pattern from a dose-linked one.

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u/aleksi_grimaldi28 points·4 months ago

nothing on this board is a substitute for someone who knows your history

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u/reads_the_wiki32 points·4 months ago

That is a general statement about gastric emptying, and the question was about a specific product.

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u/valeria_cardoso-10 points·4 months ago

Is this a PCOS diagnosis or an insulin resistance finding?

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u/santiago_villalobos37 points·4 months ago

Insulin resistance is a common feature in PCOS, which is why the metabolic conversation overlaps so heavily with this board. A diagnosis and a finding are still different things and the distinction matters for what the evidence says.

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u/step_therapy_s23 points·4 months ago

Perimenopausal, or is that a separate question?

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u/greta_nilsen13 points·4 months ago

Disagree — that is a general claim about absorption and the specific question needs a pharmacist rather than a board.

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u/bastian_eriksenOP7 points·4 months ago

Correcting myself upthread: the shedding started at week 65 for me, not the week I gave.

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u/bastian_aalto8 points·4 months ago

Are you asking about the compound, the weight loss, or both?

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u/jonas_cardoso20 points·4 months ago

Are you logging the cycle alongside the dose?

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u/sena_teixeira15 points·4 months ago

Anything involving pregnancy, contraception efficacy or fertility planning belongs with a clinician. That is not a disclaimer, it is where the answers actually are.

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u/coa_forgery_watch0 points·4 months ago

Anything involving pregnancy, contraception efficacy or fertility planning belongs with a clinician.

Disagreeing with this line: the absorption question has a product-specific answer and a pharmacist has it.

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The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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