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c/glp1women·posted 13 days ago by u/yusuf_ramos

[Discussion] the trials under-powered every question in this community

Discussion Long Haul ×1

Right, the fertility question again, but with numbers this time.

I have 22 data points over 32 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 93, not week 47. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

467 up / 72 down87% upvoted10 commentsid 1vwj6217 Jul 2026

10 comments

9 in this archive, depth 3

best — the order this archive was captured in

u/hair_shed_hannahMOD66 points·12 days ago

Tracking number removed. It identifies both ends of a shipment.

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u/mei_cardoso28 points·11 days ago

Not convinced. The evidence does not support that reading.

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[removed]30 points·11 days ago

[removed by moderator]

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u/careful_gradient0 points·12 days ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/devils_advocate_d1 point·12 days ago

Strongly agree. Cycle changes are documented.

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u/yusuf_ramos24 points·12 days ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/kenji_demir7 points·12 days ago

the cycle tracking data matters, keep it private

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u/milan_wikstrom16 points·12 days ago·edited

Slight fix: the number was 98.6, not 98.7. Decimal point, but a fairly consequential one.

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u/elodie_kuipers4 points·12 days ago

cycle changes are real and under-researched

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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