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c/glp1women·posted 1 year ago by u/emeka_chowdhury

[Discussion] perimenopause is doing more work than we give it credit for

Discussion Clean Column ×9 Receipts ×2

perimenopause is doing more work than we give it credit for. It is the sort of thing everyone half-believes and nobody writes down.

Started logging the cycle in the same sheet as the dose. Three months later the pattern was obvious and it had been invisible before.

The same dose genuinely feels different at different points in the month for me. Took a year to notice and it was in the log the whole time.

Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.

Tell me where this is wrong. That is the useful part of posting it.

2,017 up / 292 down87% upvoted36 commentsid 16p1hl17 Mar 2025

36 comments

29 in this archive, depth 6

best — the order this archive was captured in

u/georgi_haddad285 points·1 year ago

Trial populations for the major programmes were not designed around the questions this board asks most often, which is why the evidence base here is genuinely thinner rather than merely harder to find.

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u/ines_boateng-33 points·1 year ago

hair shedding follows the rate of loss, not the compound

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u/usp_appendixcompendial-48 points·1 year ago

perimenopause and this overlap in ways nobody has good data on

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u/low_appetite_lisaMOD146 points·1 year ago·edited

Pointing the contraception question at a pharmacist. They can answer it properly and we cannot.

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u/emeka_chowdhuryOP84 points·1 year ago

Has this been raised with whoever prescribes?

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u/careful_gradient58 points·1 year ago

Disagree — that is a general claim about absorption and the specific question needs a pharmacist rather than a board.

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u/elin_lindqvist46 points·1 year ago

Not convinced by the attribution. That pattern tracks the cycle in your own log more closely than it tracks the dose.

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[deleted]17 points·1 year ago

[deleted]

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u/emeka_chowdhuryOP67 points·1 year ago

Asked a pharmacist about the absorption question rather than the internet. Ten minutes, clear answer, done.

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u/blunt_coldbox2999 points·1 year ago

Correction: that trial did not enrol the population being discussed, so it cannot support the claim.

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u/elodie_yilmaz47 points·1 year ago

iron and ferritin questions come up here more than anywhere else on the site

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u/signe_villalobos118 points·1 year ago

Agreed that the vocabulary here is imprecise and it causes people to answer different questions to the ones asked.

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u/elin_lindqvist127 points·1 year ago

Where in the cycle does this fall, if you are tracking it?

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u/bastian_eriksen110 points·1 year ago

Went looking for trial data on the specific question asked here and found the population had not been enrolled.

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u/karim_restrepo61 points·1 year ago

Brought the cycle-annotated log to an appointment and it changed the conversation completely.

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u/rasmus_petrescu36 points·1 year ago

The hair shedding was the thing that frightened me most and the thing that mattered least. It stopped.

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u/jonas_cardoso48 points·1 year ago

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

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u/rina_sobczak32 points·1 year ago

Same. Perimenopause overlapping with all of this is the least documented area on the whole site.

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u/ines_boateng29 points·1 year ago

This. Anything involving pregnancy or contraception goes to a clinician, and this board should keep saying so.

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u/gentle_correctionnice about it15 points·1 year ago

How many cycles has the pattern held for?

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u/cold_chromatogram21 points·1 year ago

Fertility can change with weight loss and improved insulin sensitivity. That is a well-described phenomenon and worth knowing about in advance rather than discovering.

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u/emeka_chowdhuryOP8 points·1 year ago

PCOS is a diagnosis, not a description, and it matters which you mean

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u/neha_falk5 points·1 year ago

Push back: PCOS as a diagnosis and insulin resistance as a finding are not interchangeable, and the thread is using them as one.

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u/kian_solberg18 points·1 year ago

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

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u/blunt_coldbox_notes6 points·1 year ago

PCOS and insulin resistance are the thread that runs through this board

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u/foam_head_fred10 points·1 year ago

symptom patterns can track the cycle rather than the dose

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u/sena_teixeira6 points·1 year ago

Is this a PCOS diagnosis or an insulin resistance finding?

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The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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