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c/glp1women·posted 1 months ago by u/mateusz_mensah

stalled for 2 weeks at 12.5mg and I refuse to panic this time

Caution Clean Column ×8

stalled for 2 weeks at 12.5mg and I refuse to panic this time. It is the sort of thing everyone half-believes and nobody writes down.

The relevant figures are 2 weeks and 12.5mg, and they come from the same log I have kept the whole time.

The same dose genuinely feels different at different points in the month for me. Took a year to notice and it was in the log the whole time.

Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.

Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.

1,359 up / 464 down75% upvoted67 commentsid 15ukpf22 Jun 2026

67 comments

28 in this archive, depth 5

best — the order this archive was captured in

u/signe_villalobos108 points·1 months ago

Insulin resistance is a common feature in PCOS, which is why the metabolic conversation overlaps so heavily with this board. A diagnosis and a finding are still different things and the distinction matters for what the evidence says.

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u/hair_shed_hannahMOD60 points·1 months ago

Retitled to distinguish a cycle-linked pattern from a dose-linked one.

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u/dose_creep_dan15 points·1 months ago

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

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u/mateusz_mensahOP58 points·1 months ago

cycle timing changes how the same week feels

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[removed]28 points·1 months ago

[removed by moderator]

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u/gentle_correctionnice about it34 points·1 months ago·edited

hair shedding follows the rate of loss, not the compound

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u/ilias_steiner-6 points·1 months ago

perimenopause and this overlap in ways nobody has good data on

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u/milan_wikstrom1 point·1 months ago

Careful — anything touching pregnancy is not a board question in any form.

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u/ferran_laurent1 point·1 months ago

PCOS and insulin resistance are the thread that runs through this board

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u/ewan_zielinski0 points·1 months ago

Hormonal variation across the cycle affects appetite, fluid retention and subjective symptom intensity independently of anything else, which is why an unannotated log can look mysterious.

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u/idris_kimani1 point·1 months ago

Has this been raised with whoever prescribes?

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u/mateusz_mensahOP1 point·1 months ago

contraception absorption questions are real and they are worth asking about properly

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u/viktor_laurent1 point·1 months ago

the trials were not designed to answer most of the questions asked here

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u/mateusz_achebe37 points·1 months ago

Not convinced by the attribution. That pattern tracks the cycle in your own log more closely than it tracks the dose.

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u/greta_nilsen17 points·1 months ago·edited

Not convinced by the attribution.

Disagreeing with this line: the absorption question has a product-specific answer and a pharmacist has it.

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u/georgi_haddad21 points·1 months ago

Went looking for trial data on the specific question asked here and found the population had not been enrolled.

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u/vito_beaulieu13 points·1 months ago

Went looking for trial data on the specific question asked here and found the population had not been enrolled.

This is the practical fix for half the confusing weeks on this board — annotate the cycle.

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u/greta_nilsen16 points·1 months ago

Fertility can change with weight loss and improved insulin sensitivity. That is a well-described phenomenon and worth knowing about in advance rather than discovering.

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u/step_therapy_s5 points·1 months ago

Yes — hair shedding tracks the rate of loss and it is temporary. That reassurance is worth repeating.

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u/valeria_cardoso2 points·1 months ago

the same dose can feel different at different points in the month

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u/santiago_villalobos13 points·1 months ago

symptom patterns can track the cycle rather than the dose

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u/honest_syringe6 points·1 months ago

Agreed — logging the cycle alongside everything else is what made my own pattern visible. It was invisible before that.

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u/sena_teixeira11 points·1 months ago

Asked a pharmacist about the absorption question rather than the internet. Ten minutes, clear answer, done.

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u/dose_creep_dan4 points·1 months ago

This. Anything involving pregnancy or contraception goes to a clinician, and this board should keep saying so.

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About c/glp1women

The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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