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c/glp1women·posted 1 year ago by u/zeynep_weiss

[Results] 24 weeks on 12.5mg, full numbers, ask me anything boring

Results Slow Clap ×5

Six-word version is the title — 24 weeks on 12.5mg, full numbers, ask me anything boring — and the rest is context.

Hard numbers: 24 weeks and 12.5mg. Anything softer than that is flagged as an impression.

Questions about oral contraceptive absorption and gastric emptying are legitimate pharmacology questions with product-specific answers. A pharmacist can answer them properly; a board cannot.

Fertility can change with weight loss and improved insulin sensitivity. That is a well-described phenomenon and worth knowing about in advance rather than discovering.

Research-use-only material is not approved for human use and nothing here should be read as a recommendation to use it.

5,255 up / 4,582 down53% upvoted31 commentsid 13d69930 May 2025

31 comments

27 in this archive, depth 5

best — the order this archive was captured in

u/gentle_correctionnice about it102 points·1 year ago

The one practical change that makes this board’s hardest questions tractable: annotate your log with the cycle.

Hormonal variation affects appetite, fluid and symptom intensity in its own right. Without the annotation, a log shows a dose, a week and a set of symptoms that appear to move at random. With it, patterns that were invisible become obvious in about three months.

Members here who have done it consistently report the same thing: the same dose feels genuinely different at different points, and knowing that in advance converts a confusing fortnight into an expected one. It also makes a much better document to bring to an appointment.

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u/low_appetite_lisa25 points·1 year ago

the same dose can feel different at different points in the month

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u/jarno_karlsen9 points·1 year ago

Perimenopause and all of this at once, and there is essentially nothing written about the combination anywhere.

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u/samir_falk2 points·1 year ago

Have you asked a pharmacist about the absorption question specifically?

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u/ferran_mensah29 points·1 year ago

Perimenopausal, or is that a separate question?

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u/zeynep_weissOP18 points·1 year ago

Perimenopausal, or is that a separate question?

Adding the one thing nobody warns about — fertility can change, and quickly.

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u/dose_creep_dan13 points·1 year ago

cycle timing changes how the same week feels

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u/cold_chromatogram91 points·1 year ago

The questions that leave this board, and where they go.

Anything about pregnancy, planning a pregnancy, or contraception efficacy goes to a clinician. Absorption questions about a specific oral product go to a pharmacist, who can look it up in minutes. Fertility changes with weight loss are well described and worth raising with whoever prescribes, in advance rather than afterwards.

What stays here usefully: experience, cycle-annotated patterns, the vocabulary, and the collective knowledge that a research gap exists. That is a genuinely valuable set of things and it is a smaller set than people arriving here expect. Nothing on this board is medical advice and on this board that is not a formality.

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u/nayeli_iyer53 points·1 year ago

Started logging the cycle in the same sheet as the dose. Three months later the pattern was obvious and it had been invisible before.

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u/dilara_szabo43 points·1 year ago

Careful — anything touching pregnancy is not a board question in any form.

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[removed]29 points·1 year ago

[removed by moderator]

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u/signe_villalobos24 points·1 year ago·edited

Fertility changed faster than I expected with the weight loss. Nobody had raised it and I wish somebody had.

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u/mateusz_achebe10 points·1 year ago

Right, and symptom patterns tracking the cycle rather than the dose explains a lot of confusing weeks.

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u/ferran_laurent17 points·1 year ago·edited

Started logging the cycle in the same sheet as the dose.

Disagreeing with this line: the absorption question has a product-specific answer and a pharmacist has it.

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u/zeynep_weissOP8 points·1 year ago

Has this been raised with whoever prescribes?

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u/devils_advocate_d9 points·1 year ago

This. Anything involving pregnancy or contraception goes to a clinician, and this board should keep saying so.

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u/tared_twice25 points·1 year ago

Yes. The research gap is genuine; most of the trials were not designed to answer these questions.

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u/honest_syringe_20259 points·1 year ago

Agreed — logging the cycle alongside everything else is what made my own pattern visible. It was invisible before that.

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u/anders_karlsen-22 points·1 year ago

nothing on this board is a substitute for someone who knows your history

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u/viktor_laurent1 point·1 year ago

say what you are actually asking, the vocabulary here is imprecise

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u/zeynep_weissOP1 point·1 year ago

Is this a PCOS diagnosis or an insulin resistance finding?

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u/mei_cardoso1 point·1 year ago

Are you asking about the compound, the weight loss, or both?

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u/vito_beaulieu1 point·1 year ago·edited

That is a general statement about gastric emptying, and the question was about a specific product.

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u/georgi_haddad26 points·1 year ago

log the cycle alongside the dose if you want the pattern to be visible

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u/zaid_grimaldi10 points·1 year ago

I would not read one person’s cycle-linked experience as a general pattern. The variation here is enormous.

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u/signe_villalobos3 points·1 year ago

perimenopause and this overlap in ways nobody has good data on

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u/ilias_steiner3 points·1 year ago

hair shedding follows the rate of loss, not the compound

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The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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