help me understand receptor, I have read the wiki twice
Asking properly rather than in a comment on somebody else’s thread: help me understand receptor, I have read the wiki twice. Why mechanism talk keeps misleading people, including me. A mechanism tells you a direction. It does not tell you a magnitude, a timescale, or whether the pathway is operative at the exposures…
Receptor expression in a tissue is necessary but not sufficient for an effect. You also need the agonist to reach it at relevant exposure, and that is where a lot of confident mechanism talk falls down.
Which receptor arm are you attributing that to?
Right — mechanism gives you a direction. It never gives you an effect size and people use it as though it does.
Spent an evening on the receptor distribution literature and the side-effect map suddenly stopped looking random.
Right — mechanism gives you a direction.
Disagreeing with this specific inference — that is a preclinical result being read as human pharmacology.
Went looking for human data on a mechanism everybody here asserts. Found preclinical work and one small study. That was clarifying.