[Question] how do you actually verify pharmacology
how do you actually verify pharmacology. I would rather ask a basic question now than get this wrong quietly for two months. GLP-1 receptor agonism acts both peripherally — insulin secretion in a glucose-dependent way, slowed gastric emptying — and centrally, on appetite regulation. The central component is the…
Tolerance to the gastric effect develops with continued exposure while the appetite effect largely persists. That single fact explains most of the "it settles but it still works" pattern the side-effect board reports.
Careful — you have a plausible mechanism and no evidence that it is the operative one in the case you are describing.
Is there any human data on that mechanism yet?
the central appetite effect is doing more work than the gut effect
Small fix — it slows gastric emptying, it does not halt it, and the distinction matters for the mechanism you are proposing.
Disagree. That is a preclinical finding in a rodent model and you are stating it as human pharmacology.
Disagree.
the_poster_in_question_2026 is right that mechanism gives direction and not magnitude. Worth pinning.
Agreed — the incretin effect is the load-bearing concept and everything downstream reads differently once you have it.
I would not read that in vitro number across to a person. The conditions are nothing like physiological.