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c/glp1science·submitted 4 months ago by u/not_my_main_nm

[Meta] the mechanism rule is doing its job and people should stop complaining

Speculationbranch of 6 comments

Putting this to the board: the mechanism rule is doing its job and people should stop complaining. The half-life explanation was the thing that made weekly dosing intuitive for me rather than arbitrary. Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a…

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6 comments, started 4 months ago
u/runa_cabrera43 points·4 months ago

Careful — you have a plausible mechanism and no evidence that it is the operative one in the case you are describing.

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u/camila_lindqvist36 points·4 months ago·edited

Disagree. That is a preclinical finding in a rodent model and you are stating it as human pharmacology.

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u/amara_dziedzic24 points·4 months ago

read the discussion section, that is where the honesty lives

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u/vikram_mbeki8 points·4 months ago

Push back: a receptor being expressed in a tissue does not tell you the agonist reaches it at therapeutic exposure.

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u/rina_bergstrom4 points·4 months ago

the peripheral and central stories are not in competition

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[deleted]3 points·4 months ago

[deleted]

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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