reading half-life threads from 2024 and half of it aged badly
Confession thread, sort of.
I went from 15mg to 7.5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 11 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.
So now I have reflux I did not need and a data point I cannot interpret. Two lessons in one.
Posting it in the hope that somebody at week 78 reads it before doing the same thing.
best — the order this archive was captured in
mechanistic speculation is welcome if flaired as speculation
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
The half-life is 12 hours, which means week 12 is genuinely still ramp-up. Week 14 is steady state.
[removed by moderator]
Strongly agree. Central appetite is real but people overstate it.
The appetite literature is interesting but rodent models do not scale linearly to human dosing.
gastric emptying is real and explains most early nausea
- 1The evidence standard in c/vendorvetting gets called too strict about once a…6 comments in this branch · started by u/piotr_grimaldi