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c/glp1science·submitted 2 years ago by u/fatima_kowalski

gastric emptying — 12 things I got wrong before I got it right

Paperbranch of 9 comments

gastric emptying — 12 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. Started reading limitations sections first. It has changed how much weight I give to almost everything posted here. Asked a question here that I thought was stupid and got three…

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9 comments, started 2 years ago
u/emil_agyeman0 points·2 years ago

I would not read that in vitro number across to a person. The conditions are nothing like physiological.

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u/lina_ndiaye1 point·2 years ago

Which receptor arm are you attributing that to?

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u/georgi_chowdhury1 point·2 years ago

receptor distribution is why the side effects are where they are

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u/slow_logbook1 point·2 years ago

receptor distribution is why the side effects are where they are

Disagreeing with this specific inference — that is a preclinical result being read as human pharmacology.

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u/fatima_kowalskiOP-24 points·2 years ago

That study was in a rodent model. Worth stating, since the thread has been reading it as human data.

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u/split_dose_sceptic1 point·2 years ago

GIP is the arm people argue about because the biology is genuinely unsettled

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u/analog_alphabet1 point·2 years ago

I would not read that in vitro number across to a person.

This is the concept everything else on this board is downstream of.

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[deleted]1 point·2 years ago

[deleted]

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u/ferran_dahlberg1 point·2 years ago

Tried to build a mental model from mechanism alone and produced a confident prediction that the trial data flatly contradicted.

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