does receptor actually matter or is it forum lore at this point
Slightly embarrassed to be asking this, but: does receptor actually matter or is it forum lore at this point. Spent an evening on the receptor distribution literature and the side-effect map suddenly stopped looking random. Tried to build a mental model from mechanism alone and produced a confident prediction that…
Do you have the paper, or a summary of it?
The GIP question, which is the most interesting unsettled thing in this field.
Dual agonism at GIP and GLP-1 receptors produces clinical results that are robust and well replicated. What is not settled is the mechanism by which the GIP arm contributes — there is a genuine scientific argument about agonism versus antagonism at that receptor, with reasonable people and real data on both sides.
It is worth sitting with that. The clinical effect is not in doubt; the explanation is. That is an ordinary state of affairs in pharmacology and it is a good corrective to the confident mechanistic stories that circulate here.
dose response is not linear and nobody should assume it is
Went looking for human data on a mechanism everybody here asserts. Found preclinical work and one small study. That was clarifying.
Read the primary paper after arguing about the summary for a fortnight. The discussion section said almost the opposite of what the thread had concluded.
mechanism explains a direction, not a magnitude
read the discussion section, that is where the honesty lives