[Discussion] gastric emptying is doing more work than we give it credit for
gastric emptying is doing more work than we give it credit for. I have gone back and forth on this for months. The mental model, in four steps, that makes the rest of this site legible. One: gut hormones amplify the insulin response to food. Two: agonists at those receptors act peripherally on insulin secretion and…
receptor distribution is why the side effects are where they are
Was completely wrong about the gastric emptying story in a thread here two years ago. Someone corrected me with a citation and I have not made that mistake since.
The half-life explanation was the thing that made weekly dosing intuitive for me rather than arbitrary.
Not convinced by the linearity assumption. Dose-response in this class is not linear and the trials show it.
Yes. The central component is the one that explains the reports on this site better than gastric emptying does.
Does the effect persist with continued dosing or does tolerance develop?
That study was in a rodent model. Worth stating, since the thread has been reading it as human data.