does incretin actually matter or is it forum lore at this point
The title is the whole question — does incretin actually matter or is it forum lore at this point — but here is why I am asking. Went looking for human data on a mechanism everybody here asserts. Found preclinical work and one small study. That was clarifying. Tried to build a mental model from mechanism alone and…
Glucose-dependent insulin secretion is why hypoglycaemia risk is low as monotherapy: the effect scales with glycaemia rather than acting unconditionally.
Yes. The central component is the one that explains the reports on this site better than gastric emptying does.
Correction: that is glucose-dependent insulin secretion, which is why hypoglycaemia risk is low as monotherapy. Not the same claim as you made.
glucagon agonism sounds paradoxical until you read the energy expenditure work
half-life is why these are weekly and not daily
Which receptor arm are you attributing that to?
Read the primary paper after arguing about the summary for a fortnight. The discussion section said almost the opposite of what the thread had concluded.
Small fix — it slows gastric emptying, it does not halt it, and the distinction matters for the mechanism you are proposing.