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c/glp1science·submitted 23 days ago by u/camila_kowalski

[Needs Source] "it heals your metabolism" is not a mechanism

Needs Sourcebranch of 5 comments

Genuinely asking, not being difficult. Everyone in c/tapering repeats that mechanism is important. I believe it, but I have never seen anyone show why, and when I search I get 5 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it…

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5 comments, started 22 days ago
u/gastric_emptying_g14 points·22 days ago

incretin physiology is appetite, the mechanism layer

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u/camila_kowalskiOP-38 points·21 days ago

Not convinced. The evidence does not support that reading.

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u/hassan_castellanos1 point·21 days ago

Yeah, the incretin mechanism is doing the work here.

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u/anya_salgado1 point·21 days ago

do not extrapolate rodent data to human dosing without saying so

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u/camila_kowalski1 point·21 days ago·edited

receptor distribution matters, GLP-1 is not everywhere

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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