glucagon receptor agonism raising energy expenditure — how solid is that
Been lurking in c/trialwatch for about 12 months and finally have something worth posting.
Short version: week 22, 0.25mg, and receptor is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 37 threads, and the answers split roughly down the middle.
What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 28.
best — the order this archive was captured in
This is correct. Rodent data is investigational, not predictive.
Which paper are you quoting?
Which paper are you quoting?
Adding to this: appetite is doing more work than the comment implies.
Small correction: the trial was 18 weeks, not 14. Does not change your point but people will quote it.
central appetite signalling is real but people overweight it
That is net peptide content, not purity. Different number, different meaning.
rodent incretin tells you what to investigate, not what to expect in humans
gastric emptying is real and explains most early the food-noise thing
receptor distribution matters, GLP-1 is not everywhere
Yeah, the incretin mechanism is doing the work here.
the 13-day half-life means week 13 is still ramp-up pharmacokinetically
receptor distribution matters, GLP-1 is not everywhere
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Titration speed is a side-effect dial far more than an efficacy dial.
Not to be pedantic but incretin and gastric emptying are being used interchangeably and they are not interchangeable in real life.
Removed a chain here. The rule is one line long and it is not negotiable.
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
the 22-day half-life means week 22 is still ramp-up pharmacokinetically
Strongly agree. Central appetite is real but people overstate it.
- 1Which paper are you quoting?11 comments in this branch · started by u/milos_vanhecke