[Paper] receptor distribution and why the GI effects were predictable
Trying to settle this properly because the thread from last year went in circles.
The claim: gastric emptying matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 14 months without either producing anything.
What would actually settle it is 21 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
The pharmacology literature is interesting but rodent models do not scale linearly to human dosing.
Strongly agree. Central appetite is real but people overstate it.
the half-life is half-life, affects steady state timing
the 10-day half-life means week 10 is still ramp-up pharmacokinetically
the 10-day half-life means week 10 is still ramp-up pharmacokinetically
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
cite the paper: journal, year, first author, links optional
Yeah, the incretin mechanism is doing the work here.
Yeah, the incretin mechanism is doing the work here.
Adding to this: incretin is doing more work than the comment implies.
Flair changed to match the content. Read the sidebar before posting next time and we are square.
This is correct. Rodent data is investigational, not predictive.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
mechanistic speculation is welcome if flaired as speculation
Yeah, the incretin mechanism is doing the work here.
This is correct. Rodent data is investigational, not predictive.
Slight fix: the number was 96.8, not 98.6. Decimal point, but a fairly consequential one.
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
- 1The pharmacology literature is interesting but rodent models do not scale…6 comments in this branch · started by u/flair_enthusiast
- 2good post. terrible flair.5 comments in this branch · started by u/karma_irrelevant