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c/glp1muscle·posted 4 months ago by u/protein_first_p

switched from 0.25mg to 2.4mg and constipation got better, not worse

Results Receipts ×3 Cold Box ×1

switched from 0.25mg to 2.4mg and constipation got better, not worse — a position I have arrived at slowly and would like tested.

To save the first four comments: 0.25mg and 2.4mg.

DEXA has a meaningful coefficient of variation, and it differs between machines and protocols. Comparing scans from different clinics adds a systematic offset that is invisible on the report.

Some lean mass loss accompanies weight loss in any deficit. Resistance training and adequate protein intake are the two interventions with the best evidence for limiting the proportion.

Happy to answer the boring questions. Those are usually the ones worth asking.

1,153 up / 181 down86% upvoted25 commentsid 4yo7d5 Mar 2026

25 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/annika_fonseca-9 points·4 months ago

Nothing here is a training or nutrition prescription. Targets and programmes are matters for somebody who knows your history and your training background.

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u/arne_amankwah1 point·4 months ago

I would not change the programme on the strength of one scan. The measurement error is larger than the effect you are reacting to.

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u/line_demir1 point·4 months ago

strength retention is a decent proxy and it is free

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u/lift_heavy_thingsMOD76 points·4 months ago

Retitled — the original claimed a composition change the scans cannot distinguish.

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u/freya_onwuka35 points·4 months ago·edited

Yes. Lean mass change during weight loss is expected; the useful question is the proportion, not whether it happens.

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u/mikkel_correia38 points·4 months ago

Push back: strength dropping in a deficit is not the same as lean mass loss. Related, not identical.

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u/liv_dumitru42 points·4 months ago

Cosigning that protein gets harder precisely when appetite drops. That is the actual difficulty and it is logistical.

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u/protein_first_pOPnutrition0 points·4 months ago

Same DEXA machine both times?

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u/lift_heavy_thingsresistance training14 points·4 months ago

a single DEXA is a number, two is a comparison, three is a trend

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u/saskia_wojcik14 points·4 months ago

Agreed on the error margin. Quoting a DEXA to one decimal implies a precision the method does not have.

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[deleted]5 points·4 months ago

[deleted]

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u/protein_first_pOPnutrition2 points·4 months ago

Resistance training, and at what frequency?

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u/joaquin_wojcik28 points·4 months ago

Disagree — slower loss does not automatically preserve lean mass. Protein and training do the work, not the rate on its own.

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u/maren_ibarra9 points·4 months ago

Agreed — protein and resistance training. Everything else in these threads is a rounding error on those two.

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u/rina_nascimento25 points·4 months ago

Not convinced by that DEXA comparison. Different machine, different protocol, and the difference is inside the error.

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u/liv_dumitru7 points·4 months ago

nothing on this board is a training or nutrition prescription

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u/incretin_ivypharmacology12 points·4 months ago

Careful, that is a nutrition prescription aimed at another member and this board does not do those.

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Lean-mass retention during rapid weight loss: protein targets, resistance-training minimums, DEXA and BIA measurement reality, FFMI tracking, and the sarcopenia question that nobody funded a proper trial for.

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