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c/compounding·posted 1 months ago by u/sofia_nascimento

[Meta] the 503A rule is doing its job and people should stop complaining

Pricing Clean Column ×7 Well Actually ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: 503A matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 12 months without either producing anything.

What would actually settle it is 39 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

1,179 up / 83 down93% upvoted33 commentsid kawsz02 Jun 2026

33 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/ruben_cabrera99 points·1 months ago

Asked 16 compounders about API source. One told me, one dodged, one said they cannot say. The answer is the signal.

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u/sofia_nascimentoOP44 points·1 months ago

Are we talking 503A or 503B?

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u/swirl_dont_shakereconstitution31 points·1 months ago

API transparency is the question that separates good compounders from sketchy ones

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u/sofia_nascimentoOP17 points·1 months ago

Which state? Rules vary.

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u/step_count_stan5 points·1 months ago

shortage list status is API source, check the actual list

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u/prior_auth_painappeals6 points·1 months ago

API source questions are on-topic and compounders dodging them is newsworthy

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[deleted]19 points·1 months ago

[deleted]

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u/eu_apotheke_a61 points·1 months ago

Asked 16 compounders about API source.

Disagree on that part. 99.2% and 96.2% on the same vial is normal.

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u/discount_math_dm51 points·1 months ago

Strongly agree. API source transparency matters.

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u/zaid_grimaldi52 points·1 months ago

The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.

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u/gallbladder_gary67 points·1 months ago

state board rules differ, say which state

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u/runa_grimaldi16 points·1 months ago

regulatory claims need a citation to the actual rule, not interpretation

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u/rafael_ostergaard41 points·1 months ago
well that is my evening gone, thanks for the paper
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u/bilal_osei18 points·1 months ago

API transparency is the question that separates good compounders from sketchy ones

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u/priya_palacios13 points·1 months ago

Half-life is about 168 hours, so steady state lands around week 18–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/slow_logbook-27 points·1 months ago

state board rules differ, say which state

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u/sofia_nascimentoOP0 points·1 months ago

The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.

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u/jonas_eriksen1 point·1 months ago

Did they tell you their API source or dodge the question?

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u/rohan_steiner20 points·1 months ago·edited

telehealth prescriber models exist, pricing differs by state

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u/runa_grimaldi9 points·1 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/eu_apotheke_a6 points·1 months ago

telehealth costs state board plus compounding markup, total varies

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u/lukas_delgado9 points·1 months ago

Are we talking 503A or 503B?

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u/hamza_serrano2 points·1 months ago

the shortage list is temporary, it ends and compounding becomes illegal again

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u/liv_vukovic3 points·1 months ago

The 503A pharmacy I used lost their shortage list eligibility. Same day, compounding became illegal. Rules are real.

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u/food_noise_gonemaintenance1 point·1 months ago

telehealth prescriber models exist, pricing differs by state

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u/cold_chromatogram311 point·1 months ago·edited

This is correct. The shortage list does expire and the rules change.

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u/food_noise_gonemaintenance1 point·1 months ago

This is correct. The shortage list does expire and the rules change.

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u/discount_math_dm1 point·1 months ago

API source questions are on-topic and compounders dodging them is newsworthy

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u/step_therapy_s3 points·1 months ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/gallbladder_gary5 points·1 months ago

regulatory claims need a citation to the actual rule, not interpretation

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About c/compounding

Compounded GLP-1s as a supply route: the 503A/503B distinction, the shortage-list mechanics that made compounding legal and then didn't, state board rules, telehealth prescriber models, and what a compounding pharmacy will and will not tell you about its API source.

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c/compounding rules
  1. Regulatory claims need a citation to the actual rule, notice or docket.
  2. No pharmacy referral codes. Naming a pharmacy is fine; recruiting for it is not.
  3. API source questions are on-topic and pharmacies dodging them is newsworthy.
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