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c/coldchain·submitted 2 years ago by u/sterile_field_steph

[PSA] excursion is not what most of this community thinks it is

PSAbranch of 6 comments

Explainer, as requested in the last thread: excursion is not what most of this community thinks it is. A transit temperature logger records a distribution, and time above a threshold matters as much as peak temperature. That is the argument for logging rather than guessing. Gel packs are designed for a duty cycle. A…

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6 comments, started 2 years ago
u/meera_sandvik0 points·2 years ago

Lyophilisation removes the water that drives most degradation pathways. That is why the dry cake is comparatively robust and the reconstituted solution is not.

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u/maren_sorensen1 point·2 years ago

Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice interface.

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u/iman_castellanos1 point·2 years ago

a summer lane and a winter lane are different lanes

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u/priya_ogunleye1 point·2 years ago

write the reconstitution date on the vial

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u/spain_receta0 points·2 years ago

a summer lane and a winter lane are different lanes

This is the distinction that resolves most threads here — powder and solution are different problems.

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u/split_dose_sceptic1 point·2 years ago

Gel pack fully liquid on arrival, powder tested 97.6% against a claimed 97.0% afterwards. The pack had done its job for as long as it was designed to.

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