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c/coldchain·submitted 2 years ago by u/india_generic_g

[Question] New Zealand — has anyone got a straight answer on lyophilised

Questionbranch of 9 comments

New Zealand — has anyone got a straight answer on lyophilised. I am not trying to be the "source?" guy. I would just like a source. Ordered from the warehouse in Spain instead of origin and the transit went from a fortnight to 9 days. Entirely different proposition in August. A transit temperature logger records a…

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9 comments, started 2 years ago
u/adaeze_weiss25 points·2 years ago

lyophilised powder is far more forgiving than the panic threads suggest

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u/mod_cold_roommod · c/coldchain21 points·2 years ago

Gel packs are designed for a duty cycle. A liquid pack at the end of a longer-than-expected transit is a pack behaving as specified, not evidence of an excursion in the vial.

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u/nightowl_injector16 points·2 years ago

if you want to know, log it, otherwise you are guessing

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u/kian_solberg13 points·2 years ago

insulation buys hours, not days

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u/india_generic_gOP7 points·2 years ago

transit temperature is a distribution, not a number

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[removed]9 points·2 years ago

[removed by moderator]

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u/marta_ilunga10 points·2 years ago

Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice interface.

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u/india_generic_gOP8 points·2 years ago

Where in the fridge is it sitting now?

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u/rohan_steiner-18 points·2 years ago

You cannot infer potency from a temperature record. The record tells you what happened to the box; only a test tells you what happened to the material.

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Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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