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c/coldchain·posted 1 months ago by u/marit_laurent

someone explain lyophilised to me like I have not read a paper in years

Data Clean Column ×3

Trying to settle this properly because the thread from last year went in circles.

The claim: lyophilised matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 4 months without either producing anything.

What would actually settle it is 11 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.

If you have data, post the data. If you have an opinion, flair it as an opinion.

981 up / 159 down86% upvoted20 commentsid pjqgww26 Jun 2026

20 comments

13 in this archive, depth 4

best — the order this archive was captured in

u/sten_palacios91 points·1 months ago

Yeah, data logger is the only acceptable proof.

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u/tidy_vialdrawer_watch2876 points·1 months ago

Do you have the logger trace?

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u/ines_lindqvist42 points·1 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/ice_pack_auditMOD25 points·1 months ago·edited

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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[removed]20 points·1 months ago

[removed by moderator]

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u/jarno_adeyemi16 points·1 months ago

Which carrier and route?

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u/mod_cold_roommod · c/coldchain16 points·1 months ago

data logger is the standard, gut feeling is not

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u/britt_okwuosa40 points·1 months ago

Strongly agree. Peak temperature is not the whole story.

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u/split_dose_sceptic0 points·1 months ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/ms_fragmenter-37 points·1 months ago

the logger trace is the data that matters, not the packaging promises

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u/emeka_beaulieu1 point·1 months ago

Yeah, data logger is the only acceptable proof.

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u/sequence_checkerresearch peptides1 point·1 months ago

a warm courier van is a bigger problem for a mixed vial than for dry powder

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u/emeka_delgado1 point·1 months ago

Yeah, data logger is the only acceptable proof.

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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About c/coldchain

Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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