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c/coldchain·submitted 1 year ago by u/soren_yildiz

ice pack — 19 things I got wrong before I got it right

Explainerbranch of 7 comments

ice pack — 19 things I got wrong before I got it right. It is the sort of thing everyone half-believes and nobody writes down. Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice…

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7 comments, started 1 year ago
u/amara_dziedzic313 points·1 year ago

if you want to know, log it, otherwise you are guessing

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u/ferran_laurent187 points·1 year ago

if you want to know, log it, otherwise you are guessing

This is the distinction that resolves most threads here — powder and solution are different problems.

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u/soren_yildizOP366 points·1 year ago

Was there a logger in the box?

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u/rohan_steiner85 points·1 year ago

ask what storage condition the stability statement was written against

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u/soren_yildizOP0 points·1 year ago

What was the packaging — rigid outer, gel packs, anything insulating?

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u/cesar_teixeira46 points·1 year ago

Same. Door shelf is the worst place in the fridge and it is where everybody puts them.

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u/niels_norgaard123 points·1 year ago

ask which lines are held in regional stock before you order in July

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Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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