[Question] reconstituted vial left out for five hours — bin it or not
Something I noticed reading old threads that I have not seen said out loud.
The advice on cold chain in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with the same confidence.
I have listed what I think the current consensus is below. Correct me — that is the point of posting it.
best — the order this archive was captured in
Strongly agree. Peak temperature is not the whole story.
Customs clearance took 12 days. Package sat unrefrigerated during that. Powder tested clean after, reconstituted solution probably would not have.
This is correct. Dry powder is way more robust than liquid.
Do you have the logger trace?
customs clearance often breaks the cold chain, factor that in
gel packs last 4 hours, after that you are relying on the box itself
Dead space in the needle hub holds a small but non-trivial volume. On low-volume draws that can be several units.
Peak temperature and how long at that temperature?
stability after excursion is not zero, it is dose-dependent
Half-life is about 168 hours, so steady state lands around week 20–5. Practical consequence: what you feel in week 1 is not what that dose does.
The gel pack lasted 15 hours in a courier van, then liquid. Powder itself fine, the cold chain mostly died in transit.
the Netherlands to the Netherlands: 21 days with JEEP and 36 days with SSA. Same route, different carriers, variance is real.
Not to be pedantic but ice pack and cold chain are being used interchangeably and they are not interchangeable in real life.
Logger trace from my shipment: 23 hours at 17°C. Powder tested 98.6% against 98.4% claim. Tolerates more than the box implies.
This is correct. Dry powder is way more robust than liquid.
Which carrier and route?
a warm courier van is a bigger problem for a mixed vial than for dry powder
- 1The gel pack lasted 15 hours in a courier van, then liquid. Powder itself…4 comments in this branch · started by u/iman_castellanos