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c/coldchain·submitted 1 year ago by u/curious_panel_only

reading data logger threads from 2024 and half of it aged badly

Databranch of 13 comments

reading data logger threads from 2024 and half of it aged badly. Change my mind, genuinely — I have no stake in being right about this. Regional stock changes the question rather than answering it: shorter lanes mean less exposure and fewer variables, which is why the warehouse question is worth asking before…

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13 comments, started 1 year ago
u/aleksi_eriksen18 points·1 year ago

lyophilised powder is far more forgiving than the panic threads suggest

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u/ms_fragmenter0 points·1 year ago

lyophilised powder is far more forgiving than the panic threads suggest

Agreed, and a logger costs less than the vial you are worrying about.

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u/brigade_detector1 point·1 year ago

That is the ambient temperature at the destination, not the temperature inside the box. The logger measures the second one.

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u/marit_laurent1 point·1 year ago

What was the packaging — rigid outer, gel packs, anything insulating?

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u/emeka_delgado1 point·1 year ago

Agreed. The dry powder is the robust state; it is the solution that needs the care.

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u/elodie_kuipers0 points·1 year ago

Wrote the reconstitution date on the vial for the first time last year. Have never once since wondered how old a solution is.

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u/maren_sorensen0 points·1 year ago

light matters more than people think for some of these

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u/creatine_and_cardio1 point·1 year ago

Once in solution, the relevant risks are hydrolysis, aggregation and, for some sequences, oxidation. Refrigeration slows all three; freezing a solution introduces a separate risk at the ice interface.

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u/hamza_weiss1 point·1 year ago

the excursion that matters is the one after reconstitution

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u/certified_referenceQC1 point·1 year ago·edited

Agreed on seasonality. The same lane in February and August is not the same lane.

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Temperature and stability in the real world: what an excursion actually costs you, why lyophilised powder is far more forgiving than reconstituted solution, how to read a logger CSV, and how to photograph a failed shipment so the conversation with the vendor is short.

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