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c/coa·posted 11 months ago by u/tidy_vialdrawer_watch

why does nobody talk about batch

COA Well Actually ×1 Slow Clap ×2 Receipts ×3

Slightly embarrassed to be asking this, but: why does nobody talk about batch.

Spent four months confusing area% and mass% in every post I made here. One explainer thread and it clicked permanently.

Water content 3.8%, acetate 6.2%, purity 99%, net peptide about 90% of label weight. All four numbers honest, and I had to read it twice.

The document I was worried about turned out to be a re-issue with a later creation date. Asked, got the original, entirely ordinary.

Happy to answer the boring questions. Those are usually the ones worth asking.

19,241 up / 14,360 down57% upvoted28 commentsid z5ieph2 Sep 2025

28 comments

8 in this archive, depth 3

best — the order this archive was captured in

u/dario_boateng434 points·11 months ago

Area percent is the peak area of your compound over the total integrated area, at one wavelength, on one gradient. It is a relative measure of what the detector saw, not a mass fraction of the vial.

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u/tidy_vialdrawer_watchOP309 points·11 months ago

Does the lot on the vial match the lot on the page?

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u/sig_figs_sammod · analytical344 points·10 months ago

ask for the storage condition the stability statement was written against

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u/coa_janitorMOD430 points·10 months ago

Reminder: a question about a document is not an accusation about a supplier, and posts that blur the two get retitled.

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u/tidy_vialdrawer_watchOP226 points·10 months ago

My first certificate had a compound name, a percentage and a logo. I thought that was normal. It is not, and now I know what to ask for.

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u/vito_chowdhury268 points·10 months ago

Sent one vial to PeptideMeter and PeptideMeter. 98.8% and a claimed 98.0%. Cost me more than the vial and I would do it again.

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u/janek_ferrari113 points·10 months ago

Correction: that is net peptide content, not purity. Different number, different meaning, and the document says so if you read the row label.

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u/tidy_vialdrawer_watchOP269 points·10 months ago·edited

That is the catalogue certificate rather than the batch-specific one. Same layout, completely different status.

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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c/coa rules
  1. Post the full document. Cropped COAs that hide the batch number or date get removed.
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