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Single comment threadYou are looking at one branch of reading water content threads from 2024 and half of it aged badly — 28 comments in the full submission. View in context.
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c/coa·submitted 6 months ago by u/blunt_coldbox29

reading water content threads from 2024 and half of it aged badly

Questionbranch of 8 comments

reading water content threads from 2024 and half of it aged badly. It is the sort of thing everyone half-believes and nobody writes down. Net peptide content is the fraction of the powder that is actually peptide once counterion, water and residual solvent are accounted for. A 99% pure acetate salt can still be about…

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8 comments, started 6 months ago
u/foam_head_fred90 points·6 months ago

Not quite. Two labs with different gradients can resolve a close-eluting impurity differently and both be reporting honestly.

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u/santiago_szabo26 points·6 months ago

Cosigning. The batch identifier is load-bearing, and a certificate that cannot be tied to the vial in your hand is not about your vial.

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u/coa_janitorMOD48 points·6 months ago

Reminder: a question about a document is not an accusation about a supplier, and posts that blur the two get retitled.

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u/rohan_steiner71 points·6 months ago

axis labels included, always

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u/joaquin_ivaturi20 points·6 months ago

identity and quantity are two questions and most documents answer one

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u/milos_trevino48 points·6 months ago

Disagree that a lower number is automatically worse. A conservative claim that survives testing is worth more than an optimistic one that does not.

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u/blunt_coldbox29OP28 points·6 months ago

Correcting myself upthread: I said the date was missing and it is on the second page, which I had not scrolled to.

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u/blunt_coldbox29OP14 points·6 months ago

What does the method line actually say? Not the technique — the column and the gradient.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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