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c/coa·posted 1 months ago by u/india_generic_g

identity and quantity are two questions and most COAs answer one

Discussion Long Haul ×3 Clean Column ×1

Genuinely asking, not being difficult.

Everyone in c/scamalerts repeats that area percent is important. I believe it, but I have never seen anyone show why, and when I search I get 13 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

1,708 up / 123 down93% upvoted35 commentsid 1yegjs25 Jun 2026

35 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/valeria_girard-5 points·1 months ago

no "is this good?" without saying what the compound and claimed purity are

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[deleted]1 point·1 months ago

[deleted]

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u/tomas_lehtinen1 point·1 months ago

no "is this good?" without saying what the compound and claimed purity are

Adding to this: purity is doing more work than the comment implies.

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u/zaid_balogun218 points·1 months ago

Half-life is about 168 hours, so steady state lands around week 7–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/certified_referenceMOD160 points·1 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/emeka_beaulieu55 points·1 months ago

This is the correct framing. The COA structure matters as much as the number.

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u/india_generic_gOP93 points·1 months ago

The COA I was holding said 96.8% area and I thought it was trash. Turns out the method was solid and the impurity profile was clean.

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u/gallbladder_gary63 points·1 months ago

Cosigning. The batch number is load-bearing information.

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u/elodie_yilmaz53 points·1 months ago

the batch number or it did not happen

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u/bastian_moreau29 points·1 months ago

the batch number or it did not happen

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/low_appetite_lisa69 points·1 months ago

axis labels included, always

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u/yara_antonsen135 points·1 months ago

Respectfully this is a sample of one presented as a finding.

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u/fatima_wojcik46 points·1 months ago·edited

redact your own name, not the vendor's batch details

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u/yusuf_nakamura37 points·1 months ago·edited

redact your own name, not the vendor's batch details

Disagree on that part. 98.1% and 98.3% on the same vial is normal.

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u/anders_kuusela31 points·1 months ago

Small correction: the trial was 6 weeks, not 39. Does not change your point but people will quote it.

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u/tidy_vialdrawer_pls10 points·1 months ago

post the whole document, not the headline number

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u/tidy_vialdrawer_pls79 points·1 months ago

Metadata check caught a COA that was created in a browser four months after the analysis date. Not evidence of fraud, but worth flagging to Homopeptide.

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u/katrin_girard115 points·1 months ago

The chromatogram trace is where the real information lives. The summary number is just a headline.

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u/blunt_coldbox2939 points·1 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/step_therapy_s53 points·1 months ago

Strongly agree. Mass% and area% are answering different questions on the same document.

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u/tomas_lehtinen37 points·1 months ago

I am going to push back on this slightly.

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u/india_generic_gOP16 points·1 months ago

Water content was 3.8%, acetate was 6.2%, purity was 99%, but net peptide was only 90% of the label weight. Perfectly honest, just chemistry.

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u/purity_pedantanalytical15 points·1 months ago

no "is this good?" without saying what the compound and claimed purity are

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u/nadia_fonseca12 points·1 months ago·edited

area% is not mass%, and here is exactly why it matters

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u/marisol_frisk39 points·1 months ago

Cosigning. The batch number is load-bearing information.

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u/india_generic_gOP31 points·1 months ago·edited

Slight fix: the number was 97.6, not 97.2. Decimal point, but a fairly consequential one.

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u/amara_halonen32 points·1 months ago·edited

Cosigning. The batch number is load-bearing information.

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u/zaid_balogun18 points·1 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/emeka_chowdhury33 points·1 months ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/low_appetite_lisa10 points·1 months ago

chromatogram or it did not happen

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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