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c/coa·submitted 2 years ago by u/freya_baptista

how much of what we believe about batch actually comes from related substances threads

Questionbranch of 7 comments

how much of what we believe about batch actually comes from related substances threads — that is what I am asking, and I have already read the wiki twice. Ask what the stability statement was written against — temperature, light, and whether it was the lyophilised powder or the reconstituted solution. Those are three…

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7 comments, started 2 years ago
u/kavya_verhoeven215 points·2 years ago

Pushing back a little: a missing field is usually presentation, not concealment. Ask for the full document before drawing conclusions.

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u/cato_achebe133 points·2 years ago

Disagree that a lower number is automatically worse. A conservative claim that survives testing is worth more than an optimistic one that does not.

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u/hugo_bergstrom35 points·2 years ago

Did you get the chromatogram or only the summary line?

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u/priya_palacios18 points·2 years ago

a total of 0.4% tells you less than four named impurities adding to 0.6%

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u/tomas_lehtinen10 points·2 years ago

area% is not mass%, and the difference is the whole game

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u/hassan_chowdhury5 points·2 years ago

identity and quantity are two questions and most documents answer one

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u/anya_correia19 points·2 years ago

Correction: that is net peptide content, not purity. Different number, different meaning, and the document says so if you read the row label.

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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