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c/coa·submitted 17 days ago by u/teodor_lokken

[Explainer] the four things a COA must have or it is decorative

Explainerbranch of 6 comments

Short public-service post: the four things a COA must have or it is decorative. Asked CPC for the batch-specific certificate and had the full document — batch, date, method line naming the column — inside six hours. That is now my baseline for everybody. Ask what the stability statement was written against —…

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6 comments, started 16 days ago
u/honest_syringe24257 points·16 days ago

Started keeping a folder of every certificate I have been sent. The ones that itemise impurities are a small group and they are mostly the same suppliers.

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u/teodor_lokken126 points·16 days ago

The PDF creation date being later than the analysis date is usually a re-issue or a re-export. It is worth one question and it is not evidence of anything on its own.

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u/sofia_danquah95 points·16 days ago

Net peptide content is the fraction of the powder that is actually peptide once counterion, water and residual solvent are accounted for. A 99% pure acetate salt can still be about 85% peptide by mass.

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u/rohan_steiner176 points·16 days ago

Correction: that is net peptide content, not purity. Different number, different meaning, and the document says so if you read the row label.

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u/aleksi_eriksen95 points·16 days ago

batch number, date of analysis, method, individual impurities — that is the minimum set

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u/emeka_beaulieu100 points·16 days ago

net peptide content and purity are two different numbers on the same vial

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About c/coa

How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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