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c/coa·submitted 1 year ago by u/tidy_vialdrawer_pls

how much of what we believe about purity actually comes from related substances threads

Labbranch of 6 comments

Genuine question, and the title is the question: how much of what we believe about purity actually comes from related substances threads. Related substances itemised individually is a much stronger document than a single total, because it tells you the shape of the impurity profile rather than its size. Net peptide…

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6 comments, started 1 year ago
u/fatima_wojcik693 points·1 year ago

LC-MS gives you identity; UV purity gives you a relative quantity. A document with the first and not the second, or the reverse, is answering half the question.

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u/dario_vermeulen375 points·1 year ago

Disagree that a lower number is automatically worse. A conservative claim that survives testing is worth more than an optimistic one that does not.

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u/tidy_vialdrawer_plsOP498 points·1 year ago·edited

ask for the storage condition the stability statement was written against

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u/purity_pedantMOD375 points·1 year ago

Your name and address edited out of the screenshot above. The batch details are untouched and should stay.

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u/tidy_vialdrawer_plsOP0 points·1 year ago

Correction: that is net peptide content, not purity. Different number, different meaning, and the document says so if you read the row label.

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u/tidy_vialdrawer_plsOP233 points·1 year ago

Your name and address edited out of the screenshot above.

Disagree on this specific point. Two honest labs can resolve that impurity differently and report different numbers.

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