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c/coa·submitted 1 year ago by u/valeria_girard

three years of COA threads, summarised so you do not have to read them

Questionbranch of 6 comments

three years of COA threads, summarised so you do not have to read them. It is the sort of thing everyone half-believes and nobody writes down. Asked GL Biochem for the batch-specific certificate and had the full document — batch, date, method line naming the column — inside six hours. That is now my baseline for…

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6 comments, started 1 year ago
u/purity_pedantanalytical16 points·1 year ago

Cosigning. The batch identifier is load-bearing, and a certificate that cannot be tied to the vial in your hand is not about your vial.

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u/coa_janitorMOD10 points·1 year ago

Reminder: a question about a document is not an accusation about a supplier, and posts that blur the two get retitled.

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u/cesar_ivaturi7 points·1 year ago

Small fix — 214nm, not 280nm. It matters here because the impurity you are asking about barely absorbs at the longer wavelength.

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u/dead_space_doug4 points·1 year ago·edited

Agreed on asking for the storage condition. It is one line and it changes how you read the entire stability claim.

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u/tomas_lehtinen13 points·1 year ago

Yes. The structure of the document matters at least as much as the number printed on it.

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u/liv_nkemelu11 points·1 year ago

HPLC-UV and LC-MS answer different questions

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How to read a certificate of analysis and what it does and does not tell you. Area% versus mass%, identity versus quantity, water content, related substances, acetate counterions, and the difference between a vendor-supplied COA and an independent test on the vial you actually received.

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