GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of [Lab] TFC cagri — Janoshik came back 98.1% against a claimed 98.0% — 19 comments in the full submission. View in context.
435
c/cagrilintide·submitted 3 months ago by u/sanne_laurent

[Lab] TFC cagri — Janoshik came back 98.1% against a claimed 98.0%

Labbranch of 6 comments

Filing this under things worth writing down: TFC cagri — Janoshik came back 98.1% against a claimed 98.0%. Since the title puts numbers in the shop window: 98.1% and 98.0%. The tolerability tables were more informative than the headline numbers, which is usually the case and never how it gets summarised. Went looking…

Read the full submission and all 19 comments →

This branch

6 comments, started 3 months ago
u/lukas_vermeulen54 points·3 months ago

Amylin is co-secreted with insulin and acts on satiety and gastric emptying through its own receptor complexes. An amylin analogue is therefore not a variant of an incretin agonist — it is a different signalling axis.

replysharereportpermalink
u/pancreatitis_scare42 points·3 months ago

long-acting amylin is the whole point of the molecule

replysharereportpermalink
u/sanne_laurentOP26 points·3 months ago·edited

Correcting myself upthread: I gave the 92-week figure and the paper reports 43 weeks.

replysharereportpermalink
u/rafael_krastev25 points·3 months ago

Amylin is co-secreted with insulin and acts on satiety and gastric emptying through its own receptor complexes.

This is the distinction that keeps this board honest — different axis, not a stronger version of the same one.

replysharereportpermalink
u/niels_norgaard21 points·3 months ago

this is a less-travelled board and the evidence base shows it

replysharereportpermalink
load more comments (1) →

← back to the whole thread

About c/cagrilintide

Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

19kmembers
62submissions
Feb 2024created
submissions / month, last year
Sponsored

Sigma-Aldrich Standards

Certified reference materials for peptide identity and purity work.

sigmaaldrich.com
More in c/cagrilintide
c/cagrilintide rules
  1. Amylin is not a GLP-1. Posts conflating them get corrected.
  2. CagriSema ratios in trials are fixed-dose. Do not extrapolate to self-mixing.
  3. Not approved anywhere. Keep posts descriptive, not instructional.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/amylin_amyu/incretin_ivyu/ledger_mod
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →