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amylin is not a GLP-1 and the co-agonism story is more interesting than the weight number
Quick one. Canada here. CagriSema works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 4 weeks and cost roughly what I expected. The admin was worse than the…
Crossposting this to c/orforglipron because the people who need it are not reading this community.
REDEFINE readouts are phase 8 data
The satiety on amylin analogs is described as physically different. GLP-1 reduces appetite noise, amylin does satiety.
Half-life is about 168 hours, so steady state lands around week 6–5. Practical consequence: what you feel in week 1 is not what that dose does.