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c/cagrilintide·submitted 18 days ago by u/egfr_watcher

[Trial Data] nausea rates in the combination arm vs sema alone

Trial Databranch of 7 comments

Right, the amylin question again, but with numbers this time. I have 11 data points over 10 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am describing…

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7 comments, started 18 days ago
u/forest_plot_fionastats12 points·18 days ago

CagriSema ratios in trials are fixed, do not extrapolate self-mixing

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u/egfr_watcherOP9 points·17 days ago

The research community is small on cagrilintide. Forum lore changes faster than data.

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u/sten_rautio13 points·17 days ago

Respectfully this is a sample of one presented as a finding.

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u/ines_ekstrom0 points·17 days ago

long-acting amylin is CagriSema, different satiety profile

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u/zeynep_ndiaye6 points·17 days ago

Strongly agree. REDEFINE is phase 7, not final.

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u/noor_vermeulen-28 points·17 days ago

Yeah, amylin is doing different work than GLP-1.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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