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c/cagrilintide·submitted 1 year ago by u/ferran_mensah

week 45 check-in — 21kg down, sulphur burps manageable, one thing confusing me

Trial Databranch of 9 comments

week 45 check-in — 21kg down, sulphur burps manageable, one thing confusing me. Numbers below. Ask me the boring questions, they are the useful ones. Figures up front so nobody has to dig: week 45 and 21kg. Why this compound is not simply another agonist, which is how it gets described everywhere else. Amylin is…

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9 comments, started 1 year ago
u/nl_verzekering116 points·1 year ago

Combination and monotherapy arms must be read separately. Efficacy and tolerability both differ substantially between them and summaries routinely blur the two.

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u/ferran_mensahOP82 points·1 year ago

Went looking for independent results on this and found a handful across the whole site. That is the honest state of the evidence.

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u/micro_bump_mick34 points·1 year ago

Are you comparing against a GLP-1 monotherapy result? They are not comparable.

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u/ferran_mensahOP18 points·1 year ago

Do you have the publication or a summary of it?

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u/emeka_chowdhury24 points·1 year ago

amylin and GLP-1 are not redundant pathways

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u/hedda_aguirre19 points·1 year ago

independent purity data on this compound is thin

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u/nz_unfunded5 points·1 year ago·edited

Is there any independent purity data on this compound that you have seen?

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u/zeynep_weiss2 points·1 year ago

Push back: the evidence base here is thin enough that a confident ranking against the established compounds is not supportable.

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u/ferran_mensahOP78 points·1 year ago

Sent a vial to PeptideMeter because there was almost nothing on file for this compound. 98.6% against a claimed 98.0%, and I posted it because the log needs entries.

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Amylin analog pharmacology and the CagriSema combination: why amylin and GLP-1 co-agonism produces a different satiety profile, the REDEFINE readouts, and the very limited pool of people handling cagrilintide as research material.

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